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pentobarbital will lower the level or effect of lefamulin by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. Prevent coadministration of lefamulin with solid or average CYP3A inducers Except the reward outweighs hazards. Observe for lessened efficacy.pentobarbital will lessen the level or outcome of darifenacin